OpenAccessBelV2, Main, Exploration, bibRecord, 001350

Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial

Identifieur interne : 001350 ( Main/Exploration ); précédent : 001349; suivant : 001351

Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial

Auteurs : P. R. Koninckx [Belgique, Royaume-Uni] ; M. Craessaerts [Belgique] ; D. Timmerman [Belgique] ; F. Cornillie [Pays-Bas] ; S. Kennedy [Royaume-Uni]

Source :

Human Reproduction [ 0268-1161 ] ; 2008-09.

RBID : ISTEX:81DA3F404A4A595237E53699CABF50459F4D2951

Abstract

BACKGROUND Endometriosis is associated with an inflammatory response. Hence infliximab, an anti-TNF- monoclonal antibody, might relieve pain. METHODS A randomized placebo-controlled trial was designed with 21 women with severe pain and a rectovaginal nodule of at least 1 cm. After 1 month of observation, three infusions of infliximab (5 mg/kg) or placebo were given. Surgery was performed 3 months later and follow-up continued for 6 months. The primary end-point was pain (dysmenorrhea, deep dyspareunia and non-menstrual pain) rated at each visit by the clinician and on a daily basis by the patient who in addition scored pain by visual analog pain scale and analgesia intake. Secondary end-points included the volume of the endometriotic nodule, pelvic tenderness and the visual appearance of endometriotic lesions at laparoscopy. RESULTS Pain severity decreased during the treatment by 30 in both the placebo (P < 0.001) and infliximab groups (P < 0.001). However, no effect of infliximab was observed for any of the outcome measures. After surgery, pain scores decreased in both groups to less than 20 of the initial value. CONCLUSIONS Infliximab appears not to affect pain associated with deep endometriosis. Treatment is associated with an important placebo effect. After surgery, pain decreases to less than 20. Trials registration number ClinicalTrials.gov: NCT00604864.

Url:

https://api.istex.fr/document/81DA3F404A4A595237E53699CABF50459F4D2951/fulltext/pdf

DOI: 10.1093/humrep/den177

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000E42
to stream Istex, to step Curation: 000E33
to stream Istex, to step Checkpoint: 000E36
to stream Main, to step Merge: 001353
to stream Main, to step Curation: 001350

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial</title>
<author><name sortKey="Koninckx, P R" sort="Koninckx, P R" uniqKey="Koninckx P" first="P. R." last="Koninckx">P. R. Koninckx</name>
</author>
<author><name sortKey="Craessaerts, M" sort="Craessaerts, M" uniqKey="Craessaerts M" first="M." last="Craessaerts">M. Craessaerts</name>
</author>
<author><name sortKey="Timmerman, D" sort="Timmerman, D" uniqKey="Timmerman D" first="D." last="Timmerman">D. Timmerman</name>
</author>
<author><name sortKey="Cornillie, F" sort="Cornillie, F" uniqKey="Cornillie F" first="F." last="Cornillie">F. Cornillie</name>
</author>
<author><name sortKey="Kennedy, S" sort="Kennedy, S" uniqKey="Kennedy S" first="S." last="Kennedy">S. Kennedy</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:81DA3F404A4A595237E53699CABF50459F4D2951</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1093/humrep/den177</idno>
<idno type="url">https://api.istex.fr/document/81DA3F404A4A595237E53699CABF50459F4D2951/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000E42</idno>
<idno type="wicri:Area/Istex/Curation">000E33</idno>
<idno type="wicri:Area/Istex/Checkpoint">000E36</idno>
<idno type="wicri:doubleKey">0268-1161:2008:Koninckx P:anti:tnf:treatment</idno>
<idno type="wicri:Area/Main/Merge">001353</idno>
<idno type="wicri:Area/Main/Curation">001350</idno>
<idno type="wicri:Area/Main/Exploration">001350</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial</title>
<author><name sortKey="Koninckx, P R" sort="Koninckx, P R" uniqKey="Koninckx P" first="P. R." last="Koninckx">P. R. Koninckx</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven</wicri:regionArea>
<wicri:noRegion>B3000 Leuven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Craessaerts, M" sort="Craessaerts, M" uniqKey="Craessaerts M" first="M." last="Craessaerts">M. Craessaerts</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven</wicri:regionArea>
<wicri:noRegion>B3000 Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Timmerman, D" sort="Timmerman, D" uniqKey="Timmerman D" first="D." last="Timmerman">D. Timmerman</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven</wicri:regionArea>
<wicri:noRegion>B3000 Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cornillie, F" sort="Cornillie, F" uniqKey="Cornillie F" first="F." last="Cornillie">F. Cornillie</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Centocor BV, Medical Affairs Europe, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kennedy, S" sort="Kennedy, S" uniqKey="Kennedy S" first="S." last="Kennedy">S. Kennedy</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Human Reproduction</title>
<idno type="ISSN">0268-1161</idno>
<idno type="eISSN">1460-2350</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2008-09">2008-09</date>
<biblScope unit="volume">23</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="2017">2017</biblScope>
<biblScope unit="page" to="2023">2023</biblScope>
</imprint>
<idno type="ISSN">0268-1161</idno>
</series>
<idno type="istex">81DA3F404A4A595237E53699CABF50459F4D2951</idno>
<idno type="DOI">10.1093/humrep/den177</idno>
<idno type="ArticleID">den177</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0268-1161</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">BACKGROUND Endometriosis is associated with an inflammatory response. Hence infliximab, an anti-TNF- monoclonal antibody, might relieve pain. METHODS A randomized placebo-controlled trial was designed with 21 women with severe pain and a rectovaginal nodule of at least 1 cm. After 1 month of observation, three infusions of infliximab (5 mg/kg) or placebo were given. Surgery was performed 3 months later and follow-up continued for 6 months. The primary end-point was pain (dysmenorrhea, deep dyspareunia and non-menstrual pain) rated at each visit by the clinician and on a daily basis by the patient who in addition scored pain by visual analog pain scale and analgesia intake. Secondary end-points included the volume of the endometriotic nodule, pelvic tenderness and the visual appearance of endometriotic lesions at laparoscopy. RESULTS Pain severity decreased during the treatment by 30 in both the placebo (P < 0.001) and infliximab groups (P < 0.001). However, no effect of infliximab was observed for any of the outcome measures. After surgery, pain scores decreased in both groups to less than 20 of the initial value. CONCLUSIONS Infliximab appears not to affect pain associated with deep endometriosis. Treatment is associated with an important placebo effect. After surgery, pain decreases to less than 20. Trials registration number ClinicalTrials.gov: NCT00604864.</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Hollande-Méridionale</li>
<li>Oxfordshire</li>
</region>
<settlement><li>Leyde</li>
<li>Oxford</li>
</settlement>
<orgName><li>Université d'Oxford</li>
</orgName>
</list>
<tree><country name="Belgique"><noRegion><name sortKey="Koninckx, P R" sort="Koninckx, P R" uniqKey="Koninckx P" first="P. R." last="Koninckx">P. R. Koninckx</name>
</noRegion>
<name sortKey="Craessaerts, M" sort="Craessaerts, M" uniqKey="Craessaerts M" first="M." last="Craessaerts">M. Craessaerts</name>
<name sortKey="Timmerman, D" sort="Timmerman, D" uniqKey="Timmerman D" first="D." last="Timmerman">D. Timmerman</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Koninckx, P R" sort="Koninckx, P R" uniqKey="Koninckx P" first="P. R." last="Koninckx">P. R. Koninckx</name>
</region>
<name sortKey="Kennedy, S" sort="Kennedy, S" uniqKey="Kennedy S" first="S." last="Kennedy">S. Kennedy</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Cornillie, F" sort="Cornillie, F" uniqKey="Cornillie F" first="F." last="Cornillie">F. Cornillie</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001350 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001350 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Belgique
   |area=    OpenAccessBelV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:81DA3F404A4A595237E53699CABF50459F4D2951
   |texte=   Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial
}}

This area was generated with Dilib version V0.6.25.
Data generation: Thu Dec 1 00:43:49 2016. Site generation: Wed Mar 6 14:51:30 2024

	Serveur d'exploration autour du libre accès en Belgique
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration autour du libre accès en Belgique

Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial

Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri